CovidSeniorV1, Main, Exploration, bibRecord, 000690

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.

Identifieur interne : 000690 ( Main/Exploration ); précédent : 000689; suivant : 000691

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.

Auteurs : Sirio Fiorino [Italie] ; Claudio Gallo [Italie] ; Maddalena Zippi [Italie] ; Sergio Sabbatani [Italie] ; Roberto Manfredi [Italie] ; Renzo Moretti [Italie] ; Elisa Fogacci [Italie] ; Caterina Maggioli [Italie] ; Francesca Travasoni Loffredo [Italie] ; Enrico Giampieri [Italie] ; Ivan Corazza [Italie] ; Christoph Dickmans [Italie] ; Claudio Denitto [Italie] ; Michele Cammarosano [Italie] ; Michele Battilana [Italie] ; Paolo Emilio Orlandi [Italie] ; Francesco Del Forno [Italie] ; Francesco Miceli [Italie] ; Michela Visani [Italie] ; Giorgia Acquaviva [Italie] ; Antonio De Leo [Italie] ; Paolo Leandri [Italie] ; Wandong Hong ; Thomas Brand [Pays-Bas] ; Giovanni Tallini [Italie] ; Elio Jovine [Italie] ; Roberto Jovine [Italie] ; Dario De Biase [Italie]

Source :

Aging clinical and experimental research [ 1720-8319 ] ; 2020.

RBID : pubmed:32865757

Descripteurs français

KwdFr :
- Acide ascorbique (immunologie), Acide ascorbique (pharmacologie), Acide ascorbique (usage thérapeutique), Betacoronavirus (effets des médicaments et des substances chimiques), Betacoronavirus (immunologie), Betacoronavirus (pathogénicité), Cellules Th17 (effets des médicaments et des substances chimiques), Cellules Th17 (immunologie), Cytokines (immunologie), Humains (MeSH), Infections à coronavirus (diétothérapie), Infections à coronavirus (immunologie), Infections à coronavirus (prévention et contrôle), Infections à coronavirus (virologie), Pandémies (prévention et contrôle), Pneumopathie virale (diétothérapie), Pneumopathie virale (immunologie), Pneumopathie virale (prévention et contrôle), Pneumopathie virale (virologie), Rétinol (immunologie), Rétinol (pharmacologie), Rétinol (usage thérapeutique), Sujet âgé (MeSH), Vitamine D (immunologie), Vitamine D (pharmacologie), Vitamine D (usage thérapeutique), Vitamine E (immunologie), Vitamine E (pharmacologie), Vitamine E (usage thérapeutique), Vitamines (immunologie), Vitamines (pharmacologie), Vitamines (usage thérapeutique).
MESH :
- diétothérapie : Infections à coronavirus, Pneumopathie virale.
- effets des médicaments et des substances chimiques : Betacoronavirus, Cellules Th17.
- immunologie : Acide ascorbique, Betacoronavirus, Cellules Th17, Cytokines, Infections à coronavirus, Pneumopathie virale, Rétinol, Vitamine D, Vitamine E, Vitamines.
- pathogénicité : Betacoronavirus.
- pharmacologie : Acide ascorbique, Rétinol, Vitamine D, Vitamine E, Vitamines.
- prévention et contrôle : Infections à coronavirus, Pandémies, Pneumopathie virale.
- usage thérapeutique : Acide ascorbique, Rétinol, Vitamine D, Vitamine E, Vitamines.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Humains, Sujet âgé.

English descriptors

KwdEn :
- Aged (MeSH), Ascorbic Acid (immunology), Ascorbic Acid (pharmacology), Ascorbic Acid (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (immunology), Betacoronavirus (pathogenicity), Coronavirus Infections (diet therapy), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Cytokines (immunology), Humans (MeSH), Pandemics (prevention & control), Pneumonia, Viral (diet therapy), Pneumonia, Viral (immunology), Pneumonia, Viral (prevention & control), Pneumonia, Viral (virology), Th17 Cells (drug effects), Th17 Cells (immunology), Vitamin A (immunology), Vitamin A (pharmacology), Vitamin A (therapeutic use), Vitamin D (immunology), Vitamin D (pharmacology), Vitamin D (therapeutic use), Vitamin E (immunology), Vitamin E (pharmacology), Vitamin E (therapeutic use), Vitamins (immunology), Vitamins (pharmacology), Vitamins (therapeutic use).
MESH :
- chemical , immunology : Ascorbic Acid, Cytokines, Vitamin A, Vitamin D, Vitamin E, Vitamins.
- chemical , pharmacology : Ascorbic Acid, Vitamin A, Vitamin D, Vitamin E, Vitamins.
- chemical , therapeutic use : Ascorbic Acid, Vitamin A, Vitamin D, Vitamin E, Vitamins.
- diet therapy : Coronavirus Infections, Pneumonia, Viral.
- drug effects : Betacoronavirus, Th17 Cells.
- immunology : Betacoronavirus, Coronavirus Infections, Pneumonia, Viral, Th17 Cells.
- pathogenicity : Betacoronavirus.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Aged, Humans.

Abstract

BACKGROUND

In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a "public health emergency of international concern". A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins.

METHODS

We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function.

RESULTS

SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection.

CONCLUSIONS

Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.

DOI: 10.1007/s40520-020-01669-y
PubMed: 32865757
PubMed Central: PMC7456763

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000420
to stream Main, to step Curation: 000420

Le document en format XML

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<author><name sortKey="Visani, Michela" sort="Visani, Michela" uniqKey="Visani M" first="Michela" last="Visani">Michela Visani</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
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<author><name sortKey="Acquaviva, Giorgia" sort="Acquaviva, Giorgia" uniqKey="Acquaviva G" first="Giorgia" last="Acquaviva">Giorgia Acquaviva</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
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<author><name sortKey="De Leo, Antonio" sort="De Leo, Antonio" uniqKey="De Leo A" first="Antonio" last="De Leo">Antonio De Leo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
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<author><name sortKey="Leandri, Paolo" sort="Leandri, Paolo" uniqKey="Leandri P" first="Paolo" last="Leandri">Paolo Leandri</name>
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<wicri:regionArea>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna</wicri:regionArea>
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<author><name sortKey="Hong, Wandong" sort="Hong, Wandong" uniqKey="Hong W" first="Wandong" last="Hong">Wandong Hong</name>
<affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, The People's Republic of China.</nlm:affiliation>
<wicri:noCountry code="subField">The People's Republic of China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Brand, Thomas" sort="Brand, Thomas" uniqKey="Brand T" first="Thomas" last="Brand">Thomas Brand</name>
<affiliation wicri:level="3"><nlm:affiliation>Regenerative Medicine Center Utrecht, University of Utrecht, Utrecht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Regenerative Medicine Center Utrecht, University of Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
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<author><name sortKey="Tallini, Giovanni" sort="Tallini, Giovanni" uniqKey="Tallini G" first="Giovanni" last="Tallini">Giovanni Tallini</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
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<author><name sortKey="Jovine, Elio" sort="Jovine, Elio" uniqKey="Jovine E" first="Elio" last="Jovine">Elio Jovine</name>
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<author><name sortKey="Jovine, Roberto" sort="Jovine, Roberto" uniqKey="Jovine R" first="Roberto" last="Jovine">Roberto Jovine</name>
<affiliation wicri:level="1"><nlm:affiliation>Physical Medicine and Rehabilitation Unit, Maggiore Hospital, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Physical Medicine and Rehabilitation Unit, Maggiore Hospital, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
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<author><name sortKey="De Biase, Dario" sort="De Biase, Dario" uniqKey="De Biase D" first="Dario" last="De Biase">Dario De Biase</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
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<author><name sortKey="Fiorino, Sirio" sort="Fiorino, Sirio" uniqKey="Fiorino S" first="Sirio" last="Fiorino">Sirio Fiorino</name>
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<affiliation wicri:level="1"><nlm:affiliation>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna, Italy. sirio.fiorino@ausl.bologna.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gallo, Claudio" sort="Gallo, Claudio" uniqKey="Gallo C" first="Claudio" last="Gallo">Claudio Gallo</name>
<affiliation wicri:level="1"><nlm:affiliation>Physician Specialist in Infectious Diseases, AUSL Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Physician Specialist in Infectious Diseases, AUSL Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zippi, Maddalena" sort="Zippi, Maddalena" uniqKey="Zippi M" first="Maddalena" last="Zippi">Maddalena Zippi</name>
<affiliation wicri:level="3"><nlm:affiliation>Unit of Gastroenterology and Digestive Endoscopy, Sandro Petrini Hospital, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Gastroenterology and Digestive Endoscopy, Sandro Petrini Hospital, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabbatani, Sergio" sort="Sabbatani, Sergio" uniqKey="Sabbatani S" first="Sergio" last="Sabbatani">Sergio Sabbatani</name>
<affiliation wicri:level="1"><nlm:affiliation>Infective Disease Unit, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Infective Disease Unit, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manfredi, Roberto" sort="Manfredi, Roberto" uniqKey="Manfredi R" first="Roberto" last="Manfredi">Roberto Manfredi</name>
<affiliation wicri:level="1"><nlm:affiliation>Infective Disease Unit, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Infective Disease Unit, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moretti, Renzo" sort="Moretti, Renzo" uniqKey="Moretti R" first="Renzo" last="Moretti">Renzo Moretti</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fogacci, Elisa" sort="Fogacci, Elisa" uniqKey="Fogacci E" first="Elisa" last="Fogacci">Elisa Fogacci</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maggioli, Caterina" sort="Maggioli, Caterina" uniqKey="Maggioli C" first="Caterina" last="Maggioli">Caterina Maggioli</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Travasoni Loffredo, Francesca" sort="Travasoni Loffredo, Francesca" uniqKey="Travasoni Loffredo F" first="Francesca" last="Travasoni Loffredo">Francesca Travasoni Loffredo</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Giampieri, Enrico" sort="Giampieri, Enrico" uniqKey="Giampieri E" first="Enrico" last="Giampieri">Enrico Giampieri</name>
<affiliation wicri:level="1"><nlm:affiliation>Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Corazza, Ivan" sort="Corazza, Ivan" uniqKey="Corazza I" first="Ivan" last="Corazza">Ivan Corazza</name>
<affiliation wicri:level="1"><nlm:affiliation>Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dickmans, Christoph" sort="Dickmans, Christoph" uniqKey="Dickmans C" first="Christoph" last="Dickmans">Christoph Dickmans</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Denitto, Claudio" sort="Denitto, Claudio" uniqKey="Denitto C" first="Claudio" last="Denitto">Claudio Denitto</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cammarosano, Michele" sort="Cammarosano, Michele" uniqKey="Cammarosano M" first="Michele" last="Cammarosano">Michele Cammarosano</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Battilana, Michele" sort="Battilana, Michele" uniqKey="Battilana M" first="Michele" last="Battilana">Michele Battilana</name>
<affiliation wicri:level="1"><nlm:affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orlandi, Paolo Emilio" sort="Orlandi, Paolo Emilio" uniqKey="Orlandi P" first="Paolo Emilio" last="Orlandi">Paolo Emilio Orlandi</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Radiology, Maggiore Hospital of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Radiology, Maggiore Hospital of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Del Forno, Francesco" sort="Del Forno, Francesco" uniqKey="Del Forno F" first="Francesco" last="Del Forno">Francesco Del Forno</name>
<affiliation wicri:level="1"><nlm:affiliation>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miceli, Francesco" sort="Miceli, Francesco" uniqKey="Miceli F" first="Francesco" last="Miceli">Francesco Miceli</name>
<affiliation wicri:level="1"><nlm:affiliation>UO Farmacia Centralizzata OM, Farmacia Ospedale Di Budrio, Budrio, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UO Farmacia Centralizzata OM, Farmacia Ospedale Di Budrio, Budrio, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Visani, Michela" sort="Visani, Michela" uniqKey="Visani M" first="Michela" last="Visani">Michela Visani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Acquaviva, Giorgia" sort="Acquaviva, Giorgia" uniqKey="Acquaviva G" first="Giorgia" last="Acquaviva">Giorgia Acquaviva</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Leo, Antonio" sort="De Leo, Antonio" uniqKey="De Leo A" first="Antonio" last="De Leo">Antonio De Leo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leandri, Paolo" sort="Leandri, Paolo" uniqKey="Leandri P" first="Paolo" last="Leandri">Paolo Leandri</name>
<affiliation wicri:level="1"><nlm:affiliation>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong, Wandong" sort="Hong, Wandong" uniqKey="Hong W" first="Wandong" last="Hong">Wandong Hong</name>
<affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, The People's Republic of China.</nlm:affiliation>
<wicri:noCountry code="subField">The People's Republic of China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Brand, Thomas" sort="Brand, Thomas" uniqKey="Brand T" first="Thomas" last="Brand">Thomas Brand</name>
<affiliation wicri:level="3"><nlm:affiliation>Regenerative Medicine Center Utrecht, University of Utrecht, Utrecht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Regenerative Medicine Center Utrecht, University of Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tallini, Giovanni" sort="Tallini, Giovanni" uniqKey="Tallini G" first="Giovanni" last="Tallini">Giovanni Tallini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jovine, Elio" sort="Jovine, Elio" uniqKey="Jovine E" first="Elio" last="Jovine">Elio Jovine</name>
<affiliation wicri:level="1"><nlm:affiliation>Surgery Unit, Maggiore Hospital, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Surgery Unit, Maggiore Hospital, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jovine, Roberto" sort="Jovine, Roberto" uniqKey="Jovine R" first="Roberto" last="Jovine">Roberto Jovine</name>
<affiliation wicri:level="1"><nlm:affiliation>Physical Medicine and Rehabilitation Unit, Maggiore Hospital, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Physical Medicine and Rehabilitation Unit, Maggiore Hospital, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Biase, Dario" sort="De Biase, Dario" uniqKey="De Biase D" first="Dario" last="De Biase">Dario De Biase</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Aging clinical and experimental research</title>
<idno type="eISSN">1720-8319</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Ascorbic Acid (immunology)</term>
<term>Ascorbic Acid (pharmacology)</term>
<term>Ascorbic Acid (therapeutic use)</term>
<term>Betacoronavirus (drug effects)</term>
<term>Betacoronavirus (immunology)</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>Coronavirus Infections (diet therapy)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Coronavirus Infections (virology)</term>
<term>Cytokines (immunology)</term>
<term>Humans (MeSH)</term>
<term>Pandemics (prevention & control)</term>
<term>Pneumonia, Viral (diet therapy)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (prevention & control)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Th17 Cells (drug effects)</term>
<term>Th17 Cells (immunology)</term>
<term>Vitamin A (immunology)</term>
<term>Vitamin A (pharmacology)</term>
<term>Vitamin A (therapeutic use)</term>
<term>Vitamin D (immunology)</term>
<term>Vitamin D (pharmacology)</term>
<term>Vitamin D (therapeutic use)</term>
<term>Vitamin E (immunology)</term>
<term>Vitamin E (pharmacology)</term>
<term>Vitamin E (therapeutic use)</term>
<term>Vitamins (immunology)</term>
<term>Vitamins (pharmacology)</term>
<term>Vitamins (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide ascorbique (immunologie)</term>
<term>Acide ascorbique (pharmacologie)</term>
<term>Acide ascorbique (usage thérapeutique)</term>
<term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Betacoronavirus (immunologie)</term>
<term>Betacoronavirus (pathogénicité)</term>
<term>Cellules Th17 (effets des médicaments et des substances chimiques)</term>
<term>Cellules Th17 (immunologie)</term>
<term>Cytokines (immunologie)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (diétothérapie)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (prévention et contrôle)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Pandémies (prévention et contrôle)</term>
<term>Pneumopathie virale (diétothérapie)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (prévention et contrôle)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Rétinol (immunologie)</term>
<term>Rétinol (pharmacologie)</term>
<term>Rétinol (usage thérapeutique)</term>
<term>Sujet âgé (MeSH)</term>
<term>Vitamine D (immunologie)</term>
<term>Vitamine D (pharmacologie)</term>
<term>Vitamine D (usage thérapeutique)</term>
<term>Vitamine E (immunologie)</term>
<term>Vitamine E (pharmacologie)</term>
<term>Vitamine E (usage thérapeutique)</term>
<term>Vitamines (immunologie)</term>
<term>Vitamines (pharmacologie)</term>
<term>Vitamines (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Ascorbic Acid</term>
<term>Cytokines</term>
<term>Vitamin A</term>
<term>Vitamin D</term>
<term>Vitamin E</term>
<term>Vitamins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ascorbic Acid</term>
<term>Vitamin A</term>
<term>Vitamin D</term>
<term>Vitamin E</term>
<term>Vitamins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ascorbic Acid</term>
<term>Vitamin A</term>
<term>Vitamin D</term>
<term>Vitamin E</term>
<term>Vitamins</term>
</keywords>
<keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diétothérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Betacoronavirus</term>
<term>Cellules Th17</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Acide ascorbique</term>
<term>Betacoronavirus</term>
<term>Cellules Th17</term>
<term>Cytokines</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Rétinol</term>
<term>Vitamine D</term>
<term>Vitamine E</term>
<term>Vitamines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide ascorbique</term>
<term>Rétinol</term>
<term>Vitamine D</term>
<term>Vitamine E</term>
<term>Vitamines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pandemics</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pandémies</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide ascorbique</term>
<term>Rétinol</term>
<term>Vitamine D</term>
<term>Vitamine E</term>
<term>Vitamines</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a "public health emergency of international concern". A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32865757</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1720-8319</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>32</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Aging clinical and experimental research</Title>
<ISOAbbreviation>Aging Clin Exp Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.</ArticleTitle>
<Pagination><MedlinePgn>2115-2131</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s40520-020-01669-y</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a "public health emergency of international concern". A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fiorino</LastName>
<ForeName>Sirio</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy. sirio.fiorino@ausl.bologna.it.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna, Italy. sirio.fiorino@ausl.bologna.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gallo</LastName>
<ForeName>Claudio</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Physician Specialist in Infectious Diseases, AUSL Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zippi</LastName>
<ForeName>Maddalena</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Unit of Gastroenterology and Digestive Endoscopy, Sandro Petrini Hospital, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sabbatani</LastName>
<ForeName>Sergio</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Infective Disease Unit, University of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Manfredi</LastName>
<ForeName>Roberto</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Infective Disease Unit, University of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moretti</LastName>
<ForeName>Renzo</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fogacci</LastName>
<ForeName>Elisa</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maggioli</LastName>
<ForeName>Caterina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Travasoni Loffredo</LastName>
<ForeName>Francesca</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giampieri</LastName>
<ForeName>Enrico</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corazza</LastName>
<ForeName>Ivan</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dickmans</LastName>
<ForeName>Christoph</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Denitto</LastName>
<ForeName>Claudio</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cammarosano</LastName>
<ForeName>Michele</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Battilana</LastName>
<ForeName>Michele</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>UO of Internal Medicine Unit, Hospital of Budrio, Via Benni 44, 40065, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Orlandi</LastName>
<ForeName>Paolo Emilio</ForeName>
<Initials>PE</Initials>
<AffiliationInfo><Affiliation>Unit of Radiology, Maggiore Hospital of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Del Forno</LastName>
<ForeName>Francesco</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Miceli</LastName>
<ForeName>Francesco</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>UO Farmacia Centralizzata OM, Farmacia Ospedale Di Budrio, Budrio, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Visani</LastName>
<ForeName>Michela</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Acquaviva</LastName>
<ForeName>Giorgia</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>De Leo</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leandri</LastName>
<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Internal Medicine Unit, Maggiore Hospital of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hong</LastName>
<ForeName>Wandong</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, The People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brand</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Regenerative Medicine Center Utrecht, University of Utrecht, Utrecht, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tallini</LastName>
<ForeName>Giovanni</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jovine</LastName>
<ForeName>Elio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Surgery Unit, Maggiore Hospital, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jovine</LastName>
<ForeName>Roberto</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Physical Medicine and Rehabilitation Unit, Maggiore Hospital, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Biase</LastName>
<ForeName>Dario</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-0609-8817</Identifier>
<AffiliationInfo><Affiliation>Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>31</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Aging Clin Exp Res</MedlineTA>
<NlmUniqueID>101132995</NlmUniqueID>
<ISSNLinking>1594-0667</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014815">Vitamins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>11103-57-4</RegistryNumber>
<NameOfSubstance UI="D014801">Vitamin A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1406-16-2</RegistryNumber>
<NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1406-18-4</RegistryNumber>
<NameOfSubstance UI="D014810">Vitamin E</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>PQ6CK8PD0R</RegistryNumber>
<NameOfSubstance UI="D001205">Ascorbic Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic Acid</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000178" MajorTopicYN="Y">diet therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000178" MajorTopicYN="Y">diet therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058504" MajorTopicYN="N">Th17 Cells</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014801" MajorTopicYN="N">Vitamin A</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014810" MajorTopicYN="N">Vitamin E</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014815" MajorTopicYN="N">Vitamins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">CoV-2</Keyword>
<Keyword MajorTopicYN="N">SARS</Keyword>
<Keyword MajorTopicYN="N">Therapeutic strategy</Keyword>
<Keyword MajorTopicYN="N">Vitamins</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>06</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32865757</ArticleId>
<ArticleId IdType="doi">10.1007/s40520-020-01669-y</ArticleId>
<ArticleId IdType="pii">10.1007/s40520-020-01669-y</ArticleId>
<ArticleId IdType="pmc">PMC7456763</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Italie</li>
<li>Pays-Bas</li>
</country>
<region><li>Latium</li>
<li>Utrecht (province)</li>
</region>
<settlement><li>Rome</li>
<li>Utrecht</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Hong, Wandong" sort="Hong, Wandong" uniqKey="Hong W" first="Wandong" last="Hong">Wandong Hong</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Fiorino, Sirio" sort="Fiorino, Sirio" uniqKey="Fiorino S" first="Sirio" last="Fiorino">Sirio Fiorino</name>
</noRegion>
<name sortKey="Acquaviva, Giorgia" sort="Acquaviva, Giorgia" uniqKey="Acquaviva G" first="Giorgia" last="Acquaviva">Giorgia Acquaviva</name>
<name sortKey="Battilana, Michele" sort="Battilana, Michele" uniqKey="Battilana M" first="Michele" last="Battilana">Michele Battilana</name>
<name sortKey="Cammarosano, Michele" sort="Cammarosano, Michele" uniqKey="Cammarosano M" first="Michele" last="Cammarosano">Michele Cammarosano</name>
<name sortKey="Corazza, Ivan" sort="Corazza, Ivan" uniqKey="Corazza I" first="Ivan" last="Corazza">Ivan Corazza</name>
<name sortKey="De Biase, Dario" sort="De Biase, Dario" uniqKey="De Biase D" first="Dario" last="De Biase">Dario De Biase</name>
<name sortKey="De Leo, Antonio" sort="De Leo, Antonio" uniqKey="De Leo A" first="Antonio" last="De Leo">Antonio De Leo</name>
<name sortKey="Del Forno, Francesco" sort="Del Forno, Francesco" uniqKey="Del Forno F" first="Francesco" last="Del Forno">Francesco Del Forno</name>
<name sortKey="Denitto, Claudio" sort="Denitto, Claudio" uniqKey="Denitto C" first="Claudio" last="Denitto">Claudio Denitto</name>
<name sortKey="Dickmans, Christoph" sort="Dickmans, Christoph" uniqKey="Dickmans C" first="Christoph" last="Dickmans">Christoph Dickmans</name>
<name sortKey="Fiorino, Sirio" sort="Fiorino, Sirio" uniqKey="Fiorino S" first="Sirio" last="Fiorino">Sirio Fiorino</name>
<name sortKey="Fogacci, Elisa" sort="Fogacci, Elisa" uniqKey="Fogacci E" first="Elisa" last="Fogacci">Elisa Fogacci</name>
<name sortKey="Gallo, Claudio" sort="Gallo, Claudio" uniqKey="Gallo C" first="Claudio" last="Gallo">Claudio Gallo</name>
<name sortKey="Giampieri, Enrico" sort="Giampieri, Enrico" uniqKey="Giampieri E" first="Enrico" last="Giampieri">Enrico Giampieri</name>
<name sortKey="Jovine, Elio" sort="Jovine, Elio" uniqKey="Jovine E" first="Elio" last="Jovine">Elio Jovine</name>
<name sortKey="Jovine, Roberto" sort="Jovine, Roberto" uniqKey="Jovine R" first="Roberto" last="Jovine">Roberto Jovine</name>
<name sortKey="Leandri, Paolo" sort="Leandri, Paolo" uniqKey="Leandri P" first="Paolo" last="Leandri">Paolo Leandri</name>
<name sortKey="Maggioli, Caterina" sort="Maggioli, Caterina" uniqKey="Maggioli C" first="Caterina" last="Maggioli">Caterina Maggioli</name>
<name sortKey="Manfredi, Roberto" sort="Manfredi, Roberto" uniqKey="Manfredi R" first="Roberto" last="Manfredi">Roberto Manfredi</name>
<name sortKey="Miceli, Francesco" sort="Miceli, Francesco" uniqKey="Miceli F" first="Francesco" last="Miceli">Francesco Miceli</name>
<name sortKey="Moretti, Renzo" sort="Moretti, Renzo" uniqKey="Moretti R" first="Renzo" last="Moretti">Renzo Moretti</name>
<name sortKey="Orlandi, Paolo Emilio" sort="Orlandi, Paolo Emilio" uniqKey="Orlandi P" first="Paolo Emilio" last="Orlandi">Paolo Emilio Orlandi</name>
<name sortKey="Sabbatani, Sergio" sort="Sabbatani, Sergio" uniqKey="Sabbatani S" first="Sergio" last="Sabbatani">Sergio Sabbatani</name>
<name sortKey="Tallini, Giovanni" sort="Tallini, Giovanni" uniqKey="Tallini G" first="Giovanni" last="Tallini">Giovanni Tallini</name>
<name sortKey="Travasoni Loffredo, Francesca" sort="Travasoni Loffredo, Francesca" uniqKey="Travasoni Loffredo F" first="Francesca" last="Travasoni Loffredo">Francesca Travasoni Loffredo</name>
<name sortKey="Visani, Michela" sort="Visani, Michela" uniqKey="Visani M" first="Michela" last="Visani">Michela Visani</name>
<name sortKey="Visani, Michela" sort="Visani, Michela" uniqKey="Visani M" first="Michela" last="Visani">Michela Visani</name>
<name sortKey="Zippi, Maddalena" sort="Zippi, Maddalena" uniqKey="Zippi M" first="Maddalena" last="Zippi">Maddalena Zippi</name>
</country>
<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Brand, Thomas" sort="Brand, Thomas" uniqKey="Brand T" first="Thomas" last="Brand">Thomas Brand</name>
</region>
</country>
</tree>
</affiliations>
</record>

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       | NlmPubMed2Wicri -a CovidSeniorV1

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021

	Serveur d'exploration sur la COVID chez les séniors
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Serveur d'exploration sur la COVID chez les séniors

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.

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